Micro and Nano LC-MS columns

ChromaNik have released a range of Micro and Nano LC-MS columns with diameters from 0.5 mm down to 75 µm in different lengths. The columns are available with the SunShell high-performance core-shell materials in different particle sizes and with either C18 or Phenyl stationary phase chemistries. You can also choose the high-throughput material SunShell C8-30HT which has an exceptionally thin shell structure for extra fast separations, or the more traditional fully porous Sunniest material with C18 modification, or the SunShell C4-100 wide pore core-shell particles for separation of large molecules like monoclonal antibodies.

The ChromaNik Micro and Nano columns are highly suitable for LC-MS/MS analysis. The columns can for example contribute to higher sequence coverage and higher identification rate when mapping a tryptic digest of a BSA protein, as shown in the example below. This was achieved thanks to an efficient separation with small peak elution volume, resulting in better discrimination and higher detection sensitivity.