Degassing & Debubbling – No troubles with bubbles2024-06-19T10:45:04+02:00

NO TROUBLES WITH BUBBLES®

Degassing & Debubbling

Why degassing?

Gases dissolved in liquids often cause troubles in fluidic systems. The gas molecules can form bubbles when pressure or temperature changes, and this will affect the accuracy, precision and performance of the equipment.

Inline degassing efficiently removes dissolved gases from the fluid stream and thereby prevents bubble formation, reduces noise, improves baseline stability, reduces startup times and ensures more consistent results. This is very important in laboratory analysis equipment such as liquid chromatography, HPLC, UHPLC, ion chromatography and mass spectrometry. Machines for semi-conductor manufacturing or assembly, and instruments for immunology, hematology, and in vitro diagnostics, will also typically deliver more consistent results with a degasser included in the fluid path.

Guide to inline degasser models

  • Designed for your requirements
  • Compatible with your solvents
  • Adapted to your flow rates
  • Built for your integration needs

Inline degassing

Inline degassing is accomplished by pumping liquid through a gas-permeable tubular membrane positioned in a degassing chamber exposed to vacuum. Optimum vacuum degassing performance is achieved with a membrane having high gas-permeability. This ensures efficient and continuous gas removal, even if the liquids are transported through the degassing chamber at high flow rates. For highest user-comfort and long lifetime of the degasser, it is also important to have an intelligently regulated vacuum pump that always operate at optimum speed.

Debubbling – How it works

A debubbler is a simple tool for removal of visible bubbles from water-based liquid flow streams. The legacy debubbler design explained in the video below, resulted in significant reduction of bubbles and thus improved volume delivery precision. Nowadays, debubblers have been replaced by inline degassers, thereby removing the root cause of bubble formation.

Degassing – How it works

Efficient degassing requires high-quality components. The DEGASi® family of degassers are based on patented, cutting-edge vacuum pump and regulation technology, combined with highly efficient Systec™ AF gas-permeable membranes. Watch the video below to learn how inline vacuum degassing can help you to secure your analysis.

Why isn’t debubbling and ultrasonication sufficient?

Traditional and still rather widespread means to remove bubbles and dissolved gases are debubbling and ultrasonication. The problem is that none of these approaches are particularly efficient.

Debubbling removes only the gases that have outgassed into visible bubbles. Since this approach do not address the root cause of bubble formation, the remaining dissolved gases will likely form bubbles again and cause issues with precision in the liquid handling system. Ultrasonication typically removes about one third of the dissolved gases, and while this may reduce the tendency of bubble formation, it is often not sufficient to entirely prevent formation of bubbles. In contrast will vacuum degassing remove up to about 80% of the dissolved gases, which tend to totally eliminate any troubles with bubbles. Because of this, inline vacuum degassing is replacing inefficient approaches like debubbling and ultrasonication.

Any questions?

If you have any inquiries about our products and services, we’re here to help.

Phone: +46 300 56 91 80
Email: info@biotechfluidics.com

Learnings about liquid degassing

Interview about how Biotech Fluidics can be of help

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During the Analytica exhibition in Munich Germany, the team from LCGC International interviewed Dr. Fritiof Pontén, CEO of Biotech Fluidics, about what Biotech Fluidics can do to help customers

New convenient degasser selection guide

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Biotech Fluidics has produced a new convenient degasser selection guide covering the different models in the family of DEGASi® Stand-Alone inline degassers. This comprehensive product range have expanded rapidly

Automated flow chemistry cooperation

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During 2023, Biotech Fluidics was selected by AutoSyn AB to work on a series of enhancements for their Autonomous Chemistry Lab flow chemistry system. The Autonomous Chemistry Lab, developed

Enhancing SPR instrument performance

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Biotech Fluidics AB reports supplying key microfluidic and degassing components to BioNavis Oy (Tampere, Finland) for its range of Multi-Parametric Surface Plasmon Resonance (MP-SPR) instruments. Surface Plasmon Resonance is

The toughest degasser

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Biotech Fluidics has recently launched a new model of inline degassers, designed for full compatibility with the toughest solvents. We named it DEGASi® Integration HFIP since it can withstand

Degassers for your ÄKTA chromatography system

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Equipment for preparative purification of tagged and untagged proteins, including the ÄKTA series of liquid chromatography systems from Cytiva Life Sciences, are frequently used in settings ranging from scientific

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