Collaborations

Interview about how Biotech Fluidics can be of help

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During the Analytica exhibition in Munich Germany, the team from LCGC International interviewed Dr. Fritiof Pontén, CEO of Biotech Fluidics, about what Biotech Fluidics can do to help customers find the right solutions for their fluidic system. Dr. Pontén talked about how Biotech Fluidics on a daily basis helps original equipment manufacturers all over the world to select the right components for their instrument designs. He also explained that the company has a long experience in suppling items such as tubing, connectors, filters, degassing systems, and real time flow monitoring sensors for a wide variety of conditions. Dr. Pontén

Automated flow chemistry cooperation

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During 2023, Biotech Fluidics was selected by AutoSyn AB to work on a series of enhancements for their Autonomous Chemistry Lab flow chemistry system. The Autonomous Chemistry Lab, developed at Chalmers Technical University, Gothenburg, and commercialized by AutoSyn AB, is creating a transformative new way of doing chemistry where reaction sequences for chemical compounds are developed faster and with less resource waste than has been possible. This is achieved by combining flow chemistry methods with analytical tools and supporting AI algorithms, leading to reduced amounts of materials and time required for each process cycle. Hannes Schomaker, co-founder and CTO

Enhancing SPR instrument performance

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Biotech Fluidics AB reports supplying key microfluidic and degassing components to BioNavis Oy (Tampere, Finland) for its range of Multi-Parametric Surface Plasmon Resonance (MP-SPR) instruments. Surface Plasmon Resonance is the ‘go to’ technique for the measurement of molecular interactions in fluidics including serum, saliva, and organic solvents. SPR technology beneficially allows evaluation of affinity and kinetics of molecular binding reactions without the burdens of labelling as the technique is label-free. The BioNavis Navi™ range of advanced MP-SPR instruments provide superior features and performance enabling both studies of surface interactions as well as nanolayer characterization. Navi MP-SPR instruments are helping

Tubing kits for dissolution testing

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Did you know that Biotech Fluidics custom manufacture tubing kits for dissolution testing equipment and for other purposes? In pharmaceutical dissolution testing, the solution into which the medication is gradually dissolved, is sampled repeatedly over a certain time period at standardised conditions, to determine the rate of release of an active ingredient. Instruments for these tests are typically designed to perform several parallel experiments in separate vessels. Although sampling could be performed manually, automatic sampling and analysis allow for considerably increased throughput. Automatic sampling typically requires multiple transfer lines to be connected to each vessel for sample withdrawal. This may

High-precision dispensing facilitated by efficient degassing

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Dissolved gasses present a challenge in most liquid handling situations since off-gassing and the resulting formation of bubbles typically leads to inaccurate results. This is especially troublesome in high-precision dispensing equipment, where exact volumes of chilled solutions must be distributed at high speed during long sequences. The presence of temperature gradients and pressure differences in these setups accelerates bubble formation, which immediately impacts volume accuracy to an unacceptable level. Dispensers are therefore often furnished with alarms that stop and divert the flow if bubbles are detected, which instantly has a negative impact on throughput and productivity. The most efficient way

Eliminating bubble problems in ion chromatography

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Dissolved gasses in liquid chromatography eluents may increase background levels and can cause bubble formation that severely disturb the baseline and analyses. When performing ion chromatography separations with suppressed conductivity detection for analysis of anions, the penalties of dissolved gasses are typically poorer signal to noise ratio and consequently worse detection levels. The dissolved gasses can also lead to failed analysis if bubble formation coincide with analyte elution and thus disturb peak integration. A convenient way to eliminate all such problems is to install an online degasser between the eluent reservoir and the pump. “We have noted significantly more

Degassing in an automated RNA imaging instrumentation

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The work in the Linnarsson Lab at Karolinska Institute, aims to make high resolution atlases of the mouse and human brain, where we know the location and type of every individual cell in the brain. This is done by imaging the RNA molecules that are present in each cell of the brain with a microscope. The RNA can be seen as an intermediate between the cells' DNA and the proteins. The information of which specific RNA molecules are present in a cell tells us about the function of the cell. There are thousands of different RNA molecules that can

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