The Biotech knitted open tubular (KOT) reactors are made from tubing which has been knitted into a tortuous path to force the fast moving centre of the liquid stream to mix radially with the slower moving boundary liquid layer, thereby minimizing the axial dispersion. The shape of a chromatographic peak entering the reactor is thus preserved very efficiently. To ensure a stable radial mixing within the KOT, a linear flow rate of 10 cm/s or more is recommended. The KOT reactor is usually the most optimal delay element for use in analytical flow systems, and is typically inserted in the flow path to create a delay line, so that a reaction or other event that requires a certain time can take place. Example of applications: effecient mixing of two fluidic streams, delay coil in a fluidic system, on-line derivatization of a sample with UV light etc.